SLU-PP-332
ERR agonist (estrogen-related receptor)
An exercise-mimetic ERR agonist.
Half-life
~ hours (small molecule)
Mol. weight
290.3 g/mol (C18H14N2O2 — small molecule, not a peptide)
Sequence
N/A — synthetic small-molecule ERRα/β/γ agonist (not a peptide)
Discussions
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Overview
A synthetic ERR (estrogen-related receptor) agonist that directly activates the ERRα/β/γ nuclear receptors — the transcription factors that switch on the metabolic gene programs exercise activates, including mitochondrial biogenesis and fat oxidation. It belongs to the same 'exercise mimetic' research thread as AICAR and MOTS-c but targets a different layer of the exercise response: the nuclear-receptor transcription program rather than the energy-sensor (AMPK) layer.
Mechanism of action
SLU-PP-332 is an agonist of the estrogen-related receptors ERRα, ERRβ, and ERRγ — nuclear receptors that act as master regulators of the metabolic gene programs exercise induces: mitochondrial biogenesis, fatty-acid oxidation, oxidative phosphorylation, and endurance adaptation. By activating ERRs directly, it aims to switch on these endurance-type gene programs without the mechanical stimulus of exercise. It's mechanistically distinct from AMPK activators (AICAR, MOTS-c), which act at the energy-sensing layer upstream of transcription.
Researched benefits
- Activates ERR-driven metabolic gene programs
- Targets mitochondrial biogenesis and fat oxidation
- Studied as an exercise mimetic (endurance-program layer)
Considerations
- Preclinical; no human data
- Broad metabolic-gene effects
- Research context
Key Academic Literature & Studies
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