Exogenous GH vs Secretagogues

Somatropin replaces growth hormone directly — which works, but suppresses the body's own production and carries a different risk profile than secretagogues like sermorelin or CJC-1295 that stimulate natural release.

Members interested in GH research often weigh this trade-off: the certainty of exogenous GH versus the physiological fidelity of stimulating endogenous pulses. Exogenous GH drives IGF-1 and lipolysis reliably but brings insulin resistance, fluid retention, and feedback suppression; secretagogues preserve the body's regulation but are less potent. Both require medical supervision; neither is a casual undertaking.