HGH 191AA / Somatropin
Recombinant human growth hormone
Full growth hormone.
Half-life
~ 3–5 hours
Mol. weight
22,125 g/mol
Sequence
191 amino acid recombinant HGH (identical to native GH)
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Overview
Recombinant human growth hormone (191 amino acids), identical to native human GH and used clinically for growth disorders, adult GH deficiency, and several FDA-approved indications. As the full hormone, it replaces rather than stimulates — driving IGF-1 production, lipolysis, and tissue growth directly, but suppressing the body's own GH production in the process.
Mechanism of action
Somatropin is the full 191-amino-acid human growth hormone, identical to the native hormone. It binds GH receptors (and the GHBP splice variant) to drive hepatic IGF-1 production, lipolysis in adipose tissue, and anabolic growth across multiple tissues. Because it replaces the hormone directly rather than stimulating endogenous release, it suppresses the body's own GH production via feedback — the central distinction between exogenous GH and secretagogues like sermorelin or CJC-1295 that stimulate natural release.
Researched properties
- Clinically approved (growth disorders, adult GH deficiency)
- Improves body composition and lipolysis
- Supports recovery and tissue growth
Considerations
- Suppresses natural GH production
- Insulin resistance and fluid retention risk
- Prescription; medical supervision essential
Key Academic Literature & Studies
Search more in PubMedPeer-reviewed citations and clinical trials evaluating HGH 191AA / Somatropin in scientific literature.
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View HGH 191AA / Somatropin index on PubMed (NCBI)