GLP-1 + Glucagon: The Dual-Agonist Logic

GLP-1 agonism reduces how much you eat; glucagon agonism may increase how much energy you burn. Pairing the two on a single molecule is the logic behind dual GLP-1/glucagon agonists like mazdutide and survodutide.

This thread reviews the rationale, the differences from pure GLP-1 or GIP/GLP-1 (tirzepatide) approaches, and the open safety questions around glucagon agonism — particularly hepatic effects.