KPV
Alpha-MSH C-terminal tripeptide (Lys-Pro-Val)
The anti-inflammatory fragment.
Half-life
~ short to moderate
Mol. weight
342.4 g/mol
Sequence
Lys-Pro-Val
Discussions
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Overview
A tripeptide (Lys-Pro-Val) corresponding to the C-terminal of alpha-melanocyte-stimulating hormone (α-MSH), retaining the parent hormone's anti-inflammatory and immune-modulating properties without its pigmentary effects. Its small size and focused anti-inflammatory mechanism make it one of the most-studied short peptides for inflammatory and gut-related research.
Mechanism of action
KPV is the C-terminal tripeptide of α-MSH, and it carries the anti-inflammatory signaling of the parent melanocortin hormone while lacking the sequence responsible for pigmentary effects. It acts through melanocortin receptors and related pathways to suppress inflammatory cytokine production and modulate immune-cell activity, including in models of inflammatory bowel disease. Because it's only three amino acids, it's far more stable and economical than full α-MSH — a recurring advantage of isolating the active fragment.
Researched benefits
- Retains α-MSH's anti-inflammatory activity
- Lacks the pigmentary effects of the parent hormone
- Studied for inflammatory bowel disease models
Considerations
- Research stage
- Quality sourcing critical
- Professional guidance advised
Key Academic Literature & Studies
Search more in PubMedPeer-reviewed citations and clinical trials evaluating KPV in scientific literature.
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View KPV index on PubMed (NCBI)