GHRPs and the Hunger Trade-off

Ghrelin is the 'hunger hormone,' so any peptide that acts on ghrelin receptors can stimulate appetite. GHRP-6 is notorious for this. Ipamorelin was engineered for greater selectivity, triggering GH release with far less hunger and minimal cortisol.

That selectivity is why it's the GHRP most often paired with CJC-1295 in research protocols aimed at body composition rather than appetite. The GHRP + GHRH combination exploits the documented synergy between the two pathways — each amplifies the other's GH pulse — and ipamorelin's clean side-effect profile makes it the most tolerable GHRP for that stack.

The thread below is where members compare their experiences with the different GHRPs.