HGH Fragment 176-191
HGH C-terminal fragment (lipolytic)
The fat-burning fragment of HGH.
Half-life
~ short
Mol. weight
1817.1 g/mol
Sequence
Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Val-Phe (approx)
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Overview
A synthetic fragment corresponding to amino acids 176–191 of human growth hormone, investigated for isolating growth hormone's lipolytic (fat-burning) activity from its growth-promoting and insulin-related effects. The rationale is to retain GH's adipose-tissue signaling while shedding the IGF-1-mediated growth and insulin-antagonizing actions of the full hormone.
Mechanism of action
HGH Fragment 176-191 is the C-terminal region of growth hormone believed to mediate its lipolytic effects on adipose tissue. By using only this fragment, researchers aim to preserve fat-mobilization signaling while avoiding the broader systemic effects of full HGH — particularly IGF-1-driven growth and insulin resistance. It is closely related to AOD-9604, which is essentially this fragment with an added tyrosine for stability; both target the same lipolytic mechanism.
Researched benefits
- Isolates the lipolytic action of GH
- Aims to avoid IGF-1-mediated growth effects
- Avoids the insulin resistance of full HGH
Considerations
- Clinical evidence for meaningful fat loss remains limited
- Not approved for human use
- Strictly research context
Key Academic Literature & Studies
Search more in PubMedPeer-reviewed citations and clinical trials evaluating HGH Fragment 176-191 in scientific literature.
Query PubMed for recent peer-reviewed preclinical and clinical publications on HGH Fragment 176-191:
View HGH Fragment 176-191 index on PubMed (NCBI)