GHRP-6
Growth hormone-releasing peptide 6
The hunger-hit GHRP.
Half-life
~ 30 minutes
Mol. weight
873.0 g/mol
Sequence
His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Discussions
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Overview
A first-generation ghrelin-receptor (GHS-R1a) agonist that stimulates growth hormone release, notable among GHRPs for a pronounced appetite-stimulating effect. That hunger signal is a double-edged property: useful in research contexts seeking weight gain, less so for body-composition protocols where appetite is undesirable.
Mechanism of action
GHRP-6 agonizes the ghrelin receptor (GHS-R1a) in the pituitary and hypothalamus, stimulating growth hormone release. As a first-generation GHRP it is less receptor-selective than newer analogs like ipamorelin, and its strong ghrelin-mimetic activity produces a marked appetite-stimulating effect alongside the GH pulse — the defining characteristic that distinguishes it within the GHRP class.
Researched benefits
- Stimulates GH release
- Strong appetite stimulation (useful in weight-gain contexts)
- Synergy with GHRH analogs
Considerations
- Significant appetite stimulation
- May raise cortisol and prolactin
- Less selective than newer GHRPs
Key Academic Literature & Studies
Search more in PubMedPeer-reviewed citations and clinical trials evaluating GHRP-6 in scientific literature.
Query PubMed for recent peer-reviewed preclinical and clinical publications on GHRP-6:
View GHRP-6 index on PubMed (NCBI)