DSIP
Delta Sleep-Inducing Peptide
A neuropeptide first isolated during sleep research.
Half-life
~ short (minutes; readily degraded)
Mol. weight
848.8 g/mol
Sequence
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
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Overview
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide first isolated from the blood of sleeping animals. It is studied for its effects on sleep architecture, particularly the promotion of delta (slow-wave) sleep, and for reported modulatory effects on stress response, hormone regulation, and free-radical scavenging.
Mechanism of action
DSIP is believed to modulate sleep by influencing delta-wave (slow-wave) sleep activity and interacting with GABAergic and glutamatergic systems. It has also been reported to modulate the hypothalamic-pituitary axis (including ACTH and LH release) and to act as a free-radical scavenger, though its precise receptor and full signaling pathway remain incompletely characterized.
Researched benefits
- Promotes delta (slow-wave) sleep in animal models
- Reported stress-modulating and anxiolytic-like effects
- Studied for hypothalamic-pituitary hormone modulation
- Free-radical scavenging activity reported
Considerations
- Human clinical data is limited and inconsistent
- Mechanism not fully elucidated
- Not FDA-approved; research use only
Key Academic Literature & Studies
Search more in PubMedPeer-reviewed citations and clinical trials evaluating DSIP in scientific literature.
Query PubMed for recent peer-reviewed preclinical and clinical publications on DSIP:
View DSIP index on PubMed (NCBI)