CJC-1295 Without DAC
Modified GRF (1-29)
The pulse-preserving GHRH analog.
Half-life
~ 30 minutes
Mol. weight
3367.9 g/mol (C152H252N44O42)
Sequence
Modified GRF(1-29) — substitutions at positions 2, 8, 15, 27
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Overview
CJC-1295 without DAC — also called modified GRF(1-29) — is a shortened GHRH analog with four amino-acid substitutions that resist enzymatic degradation, extending its half-life to roughly 30 minutes. The short half-life is intentional: it produces discrete, physiological GH pulses with each dose rather than the sustained elevation of the DAC version.
Mechanism of action
Modified GRF(1-29) retains the biologically active 1-29 fragment of growth hormone-releasing hormone with substitutions (at positions 2, 8, 15, and 27) that resist DPP-4 cleavage and oxidation. It binds GHRH receptors on pituitary somatotrophs to amplify the amplitude of natural GH pulses. Because it clears within ~30 minutes, each dose produces a discrete spike that mirrors the body's pulsatile rhythm — the property that makes it the preferred GHRH analog for pulse-preserving research protocols.
Researched benefits
- Preserves physiological, pulsatile GH release
- Short half-life avoids sustained GH elevation
- Pairs well with GHRPs for synergistic pulses
Considerations
- Requires more frequent dosing than DAC
- Quality sourcing critical
- Professional guidance required
Key Academic Literature & Studies
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