Amylin: The Other Satiety Hormone

Most people researching metabolic peptides focus on GLP-1. But amylin — co-secreted with insulin from pancreatic beta cells — is an equally important satiety hormone that suppresses glucagon, slows gastric emptying, and tells the brain you're full via a distinct pathway.

Because amylin and GLP-1 reduce appetite through different mechanisms, combining the two is rational: cagrilintide (long-acting amylin) + semaglutide (GLP-1) = CagriSema, studied for additive weight loss. This thread reviews amylin biology and the combination rationale.