Adamax
Adamantane-modified Semax analog (Ac-MEHFPGP)
A newer-generation, stabilized Semax derivative.
Half-life
~ short to moderate (acetylation + adamantane extend vs native Semax)
Mol. weight
813.9 g/mol (C37H51N9O10S)
Sequence
Ac-Met-Glu-His-Phe-Pro-Gly-Pro-Ada-NH2 (adamantane-modified Semax)
Discussions
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Overview
Adamax is a synthetic designer peptide described as a next-generation derivative of Semax, built from the same ACTH(4-7) core sequence (Met-Glu-His-Phe) extended with Pro-Gly-Pro, but modified with an N-terminal acetyl group and an adamantane scaffold for greater enzymatic stability. It is discussed in cognitive-research circles for claimed pro-cognitive and stress-resilience effects, but peer-reviewed mechanistic literature remains sparse compared to the established Semax evidence base.
Mechanism of action
Adamax retains Semax's ACTH(4-7) core (MEHF), the fragment responsible for upregulating BDNF and TrkB signaling in the hippocampus, and extends it with the Pro-Gly-Pro tail as in Semax. The two added modifications — N-terminal acetylation and an adamantane (adamantyl) group — are designed to shield the peptide from exopeptidase cleavage and extend its functional half-life, the same stabilization logic used in N-acetyl epitalon. Because the peer-reviewed mechanistic literature is sparse, members treat it as early-stage and anecdote-heavy, framing discussion strictly as research-grade rather than established science.
Researched benefits
- Claimed pro-cognitive and stress-resilience effects (anecdotal)
- Stabilized ACTH(4-7) core — BDNF/TrkB pathway by design
- Adamantane modification extends enzymatic stability vs native Semax
Considerations
- Very limited peer-reviewed mechanistic data
- Not approved for human use
- Mostly anecdotal; treat with skepticism
Key Academic Literature & Studies
Search more in PubMedPeer-reviewed citations and clinical trials evaluating Adamax in scientific literature.
Query PubMed for recent peer-reviewed preclinical and clinical publications on Adamax:
View Adamax index on PubMed (NCBI)